Authors: Elsokkary M. (MD), Hussein A. (MD)

Abstract

The endometrium must be at least 9 mm thick to provide a site for proper fetal implantation and also maintains the growing baby in the later stages of gestation. If, due to any reason, this lining becomes not adequate, it becomes impossible for the blastocyst to get implanted to the uterus. It is vital for practitioners to be aware of this issue, so this study aimed to explore the effect of Plavix (75 mg) compared with aspirin (75mg) on improving the endometrial thickness in women with thin endometrium. Prospective observational study Setting: Ain Shams Maternity Hospital and Al-Azhar University (New Damietta). Patients: 500 women with thin endometrium (< 8 ml) were divided randomly into two equal arms of 250 women in each one. Intervention: Group I administered Plavix while group II received Aspirin. Endometrial pattern and thickness, uterine artery resistance and pulsatility indices, dominant follicles, and pregnancy rates of the two groups were measured. Participants’ ages ranged from 20 to 35. There was a significant effect of the two drugs in improving the endometrial thickness and pattern (trilaminar) when compared with the previous untreated cycles but there was no significant difference between Plavix and Aspirin effects as regards these parameters. Also, there was no difference between the two groups as regards uterine artery PI and RI, mean diameter of dominant follicle and pregnancy rates. Low dose aspirin and Plavix had no significant difference in increasing endometrial thickness, PI, RI of uterine artery or increasing pregnancy rates when compared to each other.

Keywords

Plavix; Aspirin; Infertility, Uterine perfusion; Endometrium

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Plavix Versus Low Dose Aspirin Effect On Uterine Perfusion in Infertile Women With Thin Endometrium: A Randomized Controlled Trial