Subclinical Hypothyroidism and Its Effect on Pregnancy Outcome

Authors: Rupali M , Dilip K. B, Santanu B, Amitava P,  Tapan K. M


A prospective analytical study was done on Eight hundred sixty nine antenatal women with singleton pregnancy at 36-38 weeks of gestation. Apart from history taking and examination maternal serum TSH and FT4 were measured. Thirty five subclinical hypothyroid mothers were noted and they were compared with 105 euthyroid pregnant women as control matched to the case in relation to age parity and ethnicity. Mother was followed up till discharge from hospital. Newborn weight, Apgar score and serum TSH after 48 hours of birth to 7 days was measured. Maternal obstetrical and perinatal outcomes were noted.  The prevalence of subclinical hypothyroidism was 4.38%. Adverse maternal outcome in subclinical hypothyroidism was associated with preeclampsia (17.14 vs. 1.90%), placental abruption (8.57 vs. 0.95%) as compared to euthyroid pregnant women. Adverse fetal outcome in subclinical hypothyroidism includes LBW (33.33 vs. 26.67%), IUGR (14.29 vs.0.95), still born (14.29 vs. 0.00%), jaundice (13.33 vs. 1.90%), and RDS (10.00 vs. 0.95%) as opposed to euthyroid women. Subclinical hypothyroidism associated with pregnancy can result in poor obstetric outcome and neonatal complications occur more frequently.


 Serum TSH, FT4, prevalence, maternal outcome, fetal outcome


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Subclinical Hypothyroidism and Its Effect on Pregnancy Outcome